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Xerostomia is a term that describes the feeling of having a dry mouth, whether as a perceived sensation or the result of salivary gland hypofunction. Regardless of cause, it manifests as a cluster of signs and symptoms encountered in dental practice frequently. While occasional mouth dryness is normal, chronic dry mouth can have devastating consequences on oral health and quality of life. Dental professionals can have a profound impact on xerostomia patients by preventing and mitigating related oral complications. Furthermore, dental professionals can educate patients on how best to cope with the condition. This course emphasizes clinical presentation, etiology, and available treatments for xerostomia. Also included is a review of popular oral health products—along with patient comments—to help practitioners guide patients through the plethora of over-the-counter treatment options.