A PEER-REVIEWED ARTICLE | by Mia L. Geisinger, DDS, MS
An increasing number of people are using glucagon-like peptide receptor agonists (GLP-1-RA) and glucose-dependent insulinotropic polypeptide receptor agonist (GIPR) medications for both glycemic control and weight loss. These medications are often referred to as “incretin mimetics,” and they target physiologic processes that are involved with dysglycemia, nutrient metabolism, and nutrient storage. Given the relative novelty of this drug class, it is important that dental health-care professionals understand their mechanisms of action, common side effects, and impacts on oral and overall health. This course will review the functions of GLP-1-RA and GIPR medications, their intended and side effects, and the clinical implications for care in the dental setting.
Educational objectives
Upon completion of this course, the dental professional should be able to:
- Describe the mechanisms of action and rationale for use of GLP-1-RA and GIPR medications
- Critically evaluate side effects of GLP-1RA and GIPR medications and their implications for dental health-care professionals
- Evaluate the impact of GLP-1RA and GIPR medications on oral health, including xerostomia, halitosis, and periodontal disease
- Understand the clinical implications for patients seeking dental care who are taking GLP-1-RA and GIPR medications
About the Author

Mia L. Geisinger, DDS, MS, is a professor and director of advanced education in periodontology at the University of Alabama at Birmingham (UAB). Dr. Geisinger received her BS in biology from Duke University, her DDS from Columbia University School of Dental Medicine, and her MS and certificate in periodontology and implantology from the University of Texas Health Science Center at San Antonio. Dr. Geisinger is a diplomate in the American Board of Periodontology. She has served as the president of the American Academy of Periodontology Foundation (AAPF), as the chair of the American Dental Association’s Council on Scientific Affairs, and on multiple national and regional organized dentistry committees. She currently serves as the vice president of the AAP and on the Board of Directors for the ADA Science & Research Institute. She has authored over 60 peer-reviewed publications, and she lectures nationally and internationally on topics in periodontology and oral health care.
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