In the United States in 2007, over 34,000 new cases of oral cavity and oropharyngeal cancer will be diagnosed. With a five-year relative survival rate estimated at 59.1% overall during 1996–2003. Early detection based on diagnoses of suspicious lesions is increased through regular screening of patients. In recent years, screening technologies have become available that supplement the visual examination. The ultimate goals are to reduce mortality and morbidity, and to improve patients’ quality of life.