Langerhans cell histiocytosis of the jawbone: A comprehensive review and report of a case with spontaneous regression

Langerhans cell histiocytosis (LCH) is a rare disease of unknown pathogenesis that involves clonal proliferation of Langerhans cells and can affect multiple human body systems. LCH’s presentation in the jaws is often mistaken for severe periodontal disease because of the bone loss pattern and attendant tooth mobility mimicking that of periodontal disease. The purpose of this article is to review the literature to highlight current diagnostic and therapeutic strategies for LCH in the jawbone. In addition, a case with spontaneous regression of an apparent isolated focal presentation of LCH in the mandible of a young man is presented. After performing a diagnostic biopsy, a conservative “wait and see” approach for treating LCH in jaws is suggested. Based on the available clinical evidence, monitoring of similar cases for a longer period is reasonable before drawing further conclusions.

Educational objectives

Upon completion of this course, the dental professional should be able to:

  1. Identify the dental and systemic clinical features of Langerhans cell histiocytosis
  2. Distinguish LCH from periodontal and endodontic lesions
  3. Describe the different modalities utilized for the management of involved teeth
  4. Identify the team members who should be involved in treating such cases

About the Authors

Hussein S. Basma, DDS, DESS, MS, is an assistant professor in the Department of Periodontology at the University of Alabama at Birmingham. He is a diplomate in the American Board of Periodontology, and lectures nationally and internationally about periodontology and implant dentistry. Dr. Basma has authored numerous peer-reviewed scientific articles and abstracts. His teaching efforts focus on bone augmentation, full-arch rehabilitation, multidisciplinary care, and integration of technology.

Muhammad H. A. Saleh, BDS, MS, MSD, is a clinical assistant professor at the University of Michigan School of Dentistry Department of Periodontics and Oral Medicine. He is actively involved in research, serving as a peer reviewer and publishing more than 50 periodontics and implant-related peer-reviewed articles. A winner of multiple national and international awards, Dr. Saleh’s research interest is primarily focused on risk factors of periodontitis and peri-implantitis, and guided bone regeneration.

Quick Access Code: 22206
Photo Credit: Nephron CC BY-SA 3.0

Not Enrolled

Course Includes

  • 1 Lesson
  • 1 Test
  • Course Certificate
  • CE credit(s): 3

    Course Type: Written

    Published Date: January 2024

    This continuing education (CE) activity was developed by Endeavor Business Media with no commercial support.

    This course was written for dentists, dental hygienists, and dental assistants, from novice to skilled.

    Educational methods: This course is a self-instructional journal and web activity.

    Provider disclosure: Endeavor Business Media neither has a leadership position nor a commercial interest in any products or services discussed or shared in this educational activity. No manufacturer or third party had any input in the development of the course content.

    Requirements for successful completion: To obtain 3 CE credits for this educational activity, you must pay the required fee, review the material, complete the course evaluation, and obtain an exam score of 70% or higher.

    CE planner disclosure: Laura Winfield, Endeavor Business Media dental group CE coordinator, neither has a leadership nor commercial interest with the products or services discussed in this educational activity. Ms. Winfield can be reached at

    Educational disclaimer: Completing a single continuing education course does not provide enough information to result in the participant being an expert in the field related to the course topic. It is a combination of many educational courses and clinical experience that allows the participant to develop skills and expertise.

    Image authenticity statement: The images in this educational activity have not been altered.

    Scientific integrity statement: Information shared in this CE course is developed from clinical research and represents the most current information available from evidence-based dentistry.

    Known benefits and limitations of the data: The information presented in this educational activity is derived from the data and information contained in the reference section.

    Registration: The cost of this CE course is $39.00 for 3 CE credits.

    Cancellation and refund policy: Any participant who is not 100% satisfied with this course can request a full refund by contacting Endeavor Business Media in writing.

    Provider information:

    Dental Board of California: Provider RP5933. Course registration number CA code: 03-5933-22206. Expires May 2027. “This course meets the Dental Board of California’s requirements for 3 units of continuing education.”


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    AGD code: 750


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