Chemical dependency is a worldwide problem and a major public health concern in the United States. To adjust for the magnitude of this crisis, The Diagnostic and Statistical Manual (DSM)-V has expanded the definition of chemical dependency. Chemical dependency causes a multitude of physiological and neurological effects in a patient, which has the potential to alter a dental professional’s treatment plan. With high relapse rates in this population, dental providers will likely encounter those in active and long-term treatment and management. This course will explore chemical dependency in the United States and focus on its etiology, diagnosis, treatment, and dental considerations.